ContactISSN:3023-6673
Author Sign-inReviewer Sign-inRegister
EnglishTürkçe
HomeAim and ScopeSpecial IssueSend ArticleLatest IssueArchiveContact Us

EFFECTS OF POTASSIUM ON HEARING

Hediye Beyza KOYUNCU,Özlem AKKOYUN SERT,Füsun Sunar

  • Hediye Beyza KOYUNCU: KTO Karatay Üniversitesi
  • Özlem AKKOYUN SERT: KTO Karatay Üniversitesi
  • Füsun Sunar: KARATAY ÜNİVERSİTESİ
  •  Year : 2024
  •  Vol : 2
  •  Issue : 2
  •  Page : 50-61
The auditory system works with the outer, middle, inner ear and auditory nerve mechanisms working together in the periphery. Any disorder that may occur in the mechanisms can cause hearing loss. These structures work in harmony among themselves and this is also seen between the perilymph and endolymph fluids in the inner ear. The ions in different concentrations in the perilymph filling the bony and the endolymph filling the membrane labyrinths must create concentration changes between the hairy cells and the fluids in order for hearing to occur. Thus, the mechanical energy reaching the inner ear must be converted into electrical energy in the hairy cells and sent to the central nervous system. Concentration changes realise hearing by working with the mechanisms of entry into the cell or exit from the cell through the channels. The mechanism of intracellular and extracellular passage is directly related to the uptake, retention and excretion of potassium. Some diseases that occur with disorders in these mechanisms are associated with a history of hearing loss. This study aimed to review the studies evaluating the effects of potassium ion, which is found in different concentrations in the body and in the inner ear, on hearing and to change the quality of life with potassium ion control in some hearing losses and to emphasise the importance of early diagnosis in potassium-related syndromic hearing losses. Studies in which dietary intake, endocochlear concentrations, canal functions and gene mutations of potassium ion were studied were included. The studies included in the review are in agreement that potassium mechanism affects hearing. However, the majority of the studies were animal experiments and studies on humans were rare. Therefore, more studies on humans are needed to directly say that potassium deficiency or excess may cause hearing loss or may have a therapeutic effect.
Cite this Article As : Koyuncu, H. B., Akkoyun Sert, Ö., & Sunar, F. (2024). Effects of potassium on hearing. Sustainable Welfare, 2(2), 50-61.

Conflict of interest : The authors declare that they have no conflict of interest.

This article is published under the CC BY-NC 4.0 license.
Sustainable Welfare
2024, Vol2, Issue2
ISSN: 3023-6673
Received : , Accepted : , Published Online :

References

  1. Belgin, E. (2017). Anatomy and physiology of the peripheral auditory system. Belgin, E., Şahlı, S., (Eds), In: Basic Audiology 2nd ed. Ankara, Türkiye: Güneş Medical Bookstores.
  2. Brown, M. R., El-Hassar, L., Zhang, Y., Alvaro, G., Large, C. H., & Kaczmarek, L. K. (2016). Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons. Journal of neurophysiology, 116(1), 106–121. https://doi.org/10.1152/jn.00174.2016
  3. Chang, Q., Tang, W., Kim, Y., & Lin, X. (2015). Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing. Neurobiology of disease, 73, 418–427. https://doi.org/10.1016/j.nbd.2014.09.005
  4. Chen, J., & Zhao, H. B. (2014). The role of an inwardly rectifying K(+) channel (Kir4.1) in the inner ear and hearing loss. Neuroscience, 265, 137–146.
  5. Diaz, R. C., Vazquez, A. E., Dou, H., Wei, D., Cardell, E. L., Lingrel, J., Shull, G. E., Doyle, K. J., & Yamoah, E. N. (2007). Conservation of hearing by simultaneous mutation of Na,K-ATPase and NKCC1. Journal of the Association for Research in Otolaryngology: JARO, 8(4), 422–434.
  6. Ding, B., Walton, J. P., Zhu, X., & Frisina, R. D. (2018). Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea. Hearing research, 367, 59–73. https://doi.org/10.1016/j.heares.2018.07.006
  7. Du, H., Ye, C., Wu, D., Zang, Y. Y., Zhang, L., Chen, C., He, X. Y., Yang, J. J., Hu, P., Xu, Z., Wan, G., & Shi, Y. S. (2020). The Cation Channel TMEM63B Is an Osmosensor Required for Hearing. Cell reports, 31(5), 107596.
  8. Erken, E. & Arınsoy, T. (2017). Potassium Metabolism Physiopathology. Arınsoy, T., Güngör Ö. Koçyiğit, İ. (Eds.), In: Kidney Pathophysiology. Türkiye: Reagent.
  9. Gelfand, S. A. (2016). Acoustic immittance assessment. In: Essential of audiology 4th ed. New York, NY: Thieme Medical Publishers, Inc.
  10. Grünert, S. C., Bodi, I., & Odening, K. E. (2017). Possible mechanisms for sensorineural hearing loss and deafness in patients with propionic acidemia. Orphanet journal of rare diseases, 12(1), 30.
  11. Hall, J. E. (Ed.). (2016a). Renal Regulation of Potassium, Calcium, Phosphate and Magnesium; Integration of Renal Mechanisms for Control of Blood Volume and Extrecellular Fluid Volume, In: Guyton and Hall Textbook of Medical Physiology 13th ed. Philadelphia, PA: Elsevier.
  12. Hall, J. E. (Ed.). (2016b). Transports of Substances Through Cell Membranes, In: Guyton and Hall Textbook of Medical Physiology 13th ed. Philadelphia, PA: Elsevier.
  13. Hall, J. E. (Ed.). (2016c). Membrane Potentials and Action Potentials, In: Guyton and Hall Textbook of Medical Physiology 13th ed. Philadelphia, PA: Elsevier.
  14. Hall, J. E. (Ed.). (2016d). The Sence of Hearing, In: Guyton and Hall Textbook of Medical Physiology 13th ed. Philadelphia, PA: Elsevier.
  15. Han, S. Y., Lee, S. Y., Suh, M. W., Lee, J. H., & Park, M. K. (2024). Insufficient nutrient intake in individuals with disabling hearing loss and the restoration of nutritional sufficiency in hearing aid users. Scientific reports, 14(1), 7509. https://doi.org/10.1038/s41598-024-57927-w
  16. Insel, P., Ross, D., Mcmahon, K. & Bernstein, M. (2017). Nutrition: 6th ed. Burlington, MA: Jones & Bartlett Learning.
  17. Jung, D. J., Lee, J. Y., Cho, K. H., Lee, K. Y., Do, J. Y., & Kang, S. H. (2019a). Association between a High-Potassium Diet and Hearing Thresholds in the Korean Adult Population. Scientific reports, 9(1), 9694.
  18. Jung, J., Lin, H., Koh, Y. I., Ryu, K., Lee, J. S., Rim, J. H., Choi, H. J., Lee, H. J., Kim, H. Y., Yu, S., Jin, H., Lee, J. H., Lee, M. G., Namkung, W., Choi, J. Y., & Gee, H. Y. (2019b). Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment. Experimental & molecular medicine, 51(8), 1–12. https://doi.org/10.1038/s12276-019-0300-9
  19. Kamakura, T., Kitahara, T., Kondo, M., Horii, A., Hanada, Y., Takimoto, Y., Ishida, Y., Nakamura, Y., Imai, T., Inohara, H., & Shimada, S. (2019). Rat Model of Ménière's Attack: Intratympanic Injection of Potassium Chloride Produces Direction-Changing Spontaneous Nystagmus and Hearing Fluctuations. Audiology & neuro-otology, 24(5), 217–223.
  20. Locher, H., de Groot, J. C., van Iperen, L., Huisman, M. A., Frijns, J. H., & Chuva de Sousa Lopes, S. M. (2015). Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss. Developmental neurobiology, 75(11), 1219–1240.
  21. Mao, H., & Chen, Y. (2021). Noise-Induced Hearing Loss: Updates on Molecular Targets and Potential Interventions. Neural plasticity, 2021, 4784385.
  22. Marinos, L., Kouvaros, S., Bizup, B., Hambach, B., Wipf, P., & Tzounopoulos, T. (2021). Transient Delivery of a KCNQ2/3-Specific Channel Activator 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus. Journal of the Association for Research in Otolaryngology : JARO, 22(2), 127–139. https://doi.org/10.1007/s10162-021-00786-3
  23. Moriyama, K., Nozaki, M., Kudo, J., Takita, A., Tatewaki, E., & Yasuda, K. (1988). Sudden deafness in a man with thyrotoxic hypokalemic periodic paralysis. Japanese journal of medicine, 27(3), 329–332. https://doi.org/10.2169/internalmedicine1962.27.329
  24. Mustapha, M., Fang, Q., Gong, T. W., Dolan, D. F., Raphael, Y., Camper, S. A., & Duncan, R. K. (2009). Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants. The Journal of neuroscience: the official journal of the Society for Neuroscience, 29(4), 1212–1223.
  25. O’Leary, S. J., & Rowe, D. P., (2014). Auditory System, Peripheral. Aminoff, M. J., Daroff, R. B. (Eds.), In: Encyclopedia of the Neurological Sciences 2nd ed. VIC, Avusturalya: Elsevier Inc.
  26. Oh, S. K., Baek, J. I., Weigand, K. M., Venselaar, H., Swarts, H. G., Park, S. H., Hashim Raza, M., Jung, D. J., Choi, S. Y., Lee, S. H., Friedrich, T., Vriend, G., Koenderink, J. B., Kim, U. K., & Lee, K. Y. (2015). A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine. European journal of human genetics: EJHG, 23(5), 639–645. https://doi.org/10.1038/ejhg.2014.154
  27. Onat, T., Emerk, K. & Sözmen, E. Y., (2006). Human Biochemistry. Ankara, Türkiye: Palme Publishing.
  28. Peixoto Pinheiro, B., Müller, M., Bös, M., Guezguez, J., Burnet, M., Tornincasa, M., Rizzetto, R., Rolland, J. F., Liberati, C., Lohmer, S., Adel, Y., & Löwenheim, H. (2022). A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss. Cell death & disease, 13(7), 595.
  29. Peixoto Pinheiro, B., Vona, B., Löwenheim, H., Rüttiger, L., Knipper, M., & Adel, Y. (2021). Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway. Pflugers Archiv: European journal of physiology, 473(5), 823–840.
  30. Salvi, R. J., Sun, W. & Lobarinas, E. (2007). Anatomy and Physiology of the Peripheral Auditory System. Salvi, J. R., Valente, M., Hosfort-Dunn, H. (Eds.), In: Audiology Diagnosis: 2nd ed. New York, NY: Thieme Medical Publishers Inc.
  31. Seikel, J. A., King, D. W., & Drumright, D.G. (2010). Anatomy of Hearing. In: Anatomy & Physiology For Speech, Language And Hearing 4th ed. New York, NY: Delmar Cengage Leaning.
  32. Sheppard, A. M., Chen, G. D., & Salvi, R. (2015). Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats. Hearing research, 327, 1–8.
  33. Sihn, C. R., Kim, H. J., Woltz, R. L., Yarov-Yarovoy, V., Yang, P. C., Xu, J., Clancy, C. E., Zhang, X. D., Chiamvimonvat, N., & Yamoah, E. N. (2016). Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. The Journal of biological chemistry, 291(5), 2499–2509. https://doi.org/10.1074/jbc.M115.668236
  34. Smith, K. E., Browne, L., Selwood, D. L., McAlpine, D., & Jagger, D. J. (2015). Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice. The Journal of neuroscience: the official journal of the Society for Neuroscience, 35(32), 11221–11232. https://doi.org/10.1523/JNEUROSCI.0496-15.2015
  35. Sun, W., Liu, J., Zhang, C., Zhou, N., Manohar, S., Winchester, W., Miranda, J. A., & Salvi, R. J. (2015). Potassium channel activator attenuates salicylate-induced cochlear hearing loss potentially ameliorating tinnitus. Frontiers in neurology, 6, 77.
  36. Thomas, P. V., Cheng, A. L., Colby, C. C., Liu, L., Patel, C. K., Josephs, L., & Duncan, R. K. (2014). Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear. Journal of proteomics, 103, 178–193. https://doi.org/10.1016/j.jprot.2014.03.037
  37. Wang, J. J., & Li, Y. (2016). KCNQ potassium channels in sensory system and neural circuits. Acta pharmacologica Sinica, 37(1), 25–33.
  38. Wu, C., V Gopal, K., Lukas, T. J., Gross, G. W., & Moore, E. J. (2014). Pharmacodynamics of potassium channel openers in cultured neuronal networks. European journal of pharmacology, 732, 68–75. https://doi.org/10.1016/j.ejphar.2014.03.017
  39. Yamaguchi, T., Nagashima, R., Yoneyama, M., Shiba, T., & Ogita, K. (2014). Disruption of ion-trafficking system in the cochlear spiral ligament prior to permanent hearing loss induced by exposure to intense noise: possible involvement of 4-hydroxy-2-nonenal as a mediator of oxidative stress. PloS one, 9(7), e102133. https://doi.org/10.1371/journal.pone.0102133
  40. Zhao, H. B., Zhu, Y., & Liu, L. M. (2021). Excess extracellular K+ causes inner hair cell ribbon synapse degeneration. Communications biology, 4(1), 24. https://doi.org/10.1038/s42003-020-01532-w